This study was performed to investigate the changes of nerve after the injection of alcohol and glycerol at the infraorbital nerve in rats.
Using the eighteen Sprague-Dawley rats, weighing 200∼250g, 99% alcohol, pure glycerol, and sterile saline was injected to the epineurium of the infraorbital nerve. Glycerol injected rats were devided into 0.01㎖, 0.03㎖ and 0.05㎖ groups. The
alcohol
and control group were injected 0.03㎖ at the left infraorbital nerve. The following results were obtained by histopathological examination after 1 week, 1 month, and 3 months.
A few inflammatory cell infiltration and no signs of nerve degeneration were noted in control group. Total nerve degeneration was noted in the alcohol group and no regeneration was noted in 1month, and partial regeneration was noted at 3month.
The
nerve
degeneration was noted at the periphery of nerve bundle in 0.01㎖ glycerol injection group. Total degeneration was noted in the 0.03㎖ and 0.05㎖ glycerol injection group and the degree was propotional to dose.
These results suggest that injection of alcohol and glycerol are effective to nerve blockage by nerve degeneration, and nerve degeneration by glycerol injection is propotional to dose and nerve regeneration by glycerol injection is inversely
propotional
to dose.
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